| 摘要 |
An object of the present invention is to provide a process for producing an optically active .gamma.-hydroxy-L-glutamic acid advantageously on an industrial scale. The present invention provides a process for producing an optically active .gamma.-hydroxy-L-glutamic acid, which comprises allowing biocatalyst I, an amino group donor, pyruvic acid and glyoxylic acid to coexist in an aqueous medium to form the optically active .gamma.-hydroxy-L-glutamic acid in the aqueous medium, and collecting the formed optically active .gamma.-hydroxy-L-glutamic acid therefrom, said biocatalyst I having activity of forming the optically active .gamma.-hydroxy-L-glutamic acid from pyruvic acid and glyoxylic acid in the presence of an amino group donor. The present invention also provides a process for producing an optically active .gamma.-hydroxy-L-glutamic acid, which comprises allowing biocatalyst II, an amino group donor and optically active 4-hydroxy-2-ketoglutaric acid to coexist in an aqueous medium to form the optically active .gamma.-hydroxy-L-glutamic acid in the aqueous medium, and collecting the formed optically active 4-hydroxy-2-ketoglutaric acid therefrom, said biocatalyst II having activity of converting an optically active 4-hydroxy-2-ketoglutaric acid into the optically active .gamma.-hydroxy-L-glutamic acid in the presence of an amino group donor.
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