摘要 |
A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one phospholipid with a first organic solvent to form a first solution, adding a clarifying amount of water to the first solution, combining a polyene with a second organic solvent to form a second solution, combining the first and second solutions to produce a substantially clear combined solution, and then removing the organic solvents, leaving a powder. |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, AUSTIN, TEX., US;ARGUS PHARMACEUTICALS, INC., THE WOODLANDS, TEX., US |
发明人 |
LENK, ROBERT P., NEW WAVERLY, TX 77358, US;MEHTA, REETA, HOUSTON, TX 77096, US;LOPEZ-BERESTEIN, GABRIEL, HOUSTON, TX 77096, US |