1-PHENOXY-3-N-ALKYLAMINOPROPAN-2-OL HALOGEN DERIVATIVES USEFUL AS MYOCARDIAL beta ADRENERGIC RECEPTOR MARKERS AND AS beta -BLOCKING AGENTS

摘要

Practolol halogenated derivatives, useful as myocardial beta adrenergic receptor markers, are of formula (I): in which R<1> can be various groups, for example, an isopropyl group, R<2> is a group of formula CH=CHX, CCX, O-(CH2)pX or OCH2CH=CHX, with X being an optionally radioactive halogen atom, R<7> is O or NHCO and n is equal to 0, 1 or 2. When X is 123I, the derivatives of the invention can be used as markers for assaying myocardial beta adrenergic receptors.