| 摘要 |
A therapeutic agent for the treatment of xerostomia comprising a derivative of spirooxathiolane-quinuclidine or an acid addition salt thereof as an active ingreient represented in the following formula ¢I!: <IMG> ¢I! (wherein R1 and R2 may be the same or different and each represents hydrogen, alkyl, cyclopentyl, cyclohexyl, aryl, diarylmethylol, or alkyl which may be substituted by one or more aryl groups). The above therapeutic agent can be administered orally or parentally and cure xerostomia. Specifically, the agent can be used for improving and/or curing dry mouth caused by various diseases with organic changes in salivary gland, lesions in salivary gland accompanied with systemic diseases, necrosis of saivary gland cell by radiotherapy, HIV infection (AIDS), hypofunction of saliva secretion, affection of various medicines taken and, further, mental fatigue or bad conditions due to complex social life situations.
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