Succinyl hydroxamic acid, n-formyl-n-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors

摘要

PCT No. PCT/GB95/01226 Sec. 371 Date Nov. 22, 1996 Sec. 102(e) Date Nov. 22, 1996 PCT Filed May 26, 1995 PCT Pub. No. WO95/32944 PCT Pub. Date Dec. 7, 1995A pharmaceutical or veterinary composition comprising a compound of formula I wherein X is a -CO2H group and R1, R2, R3, R4, R5 are as defined in the specification, or a salt, hydrate or solvate thereof, and a pharmaceutically or veterinarily acceptable excipient or carrier. A method of treatment of diseases or conditions mediated by MMPs in mammals, such as rheumatoid arthritis, osteoarthritis, periodontitis, gingivitis, corneal ulceration or tumour invasion by secondary means, by administering to the mammal an effective amount of the composition.