| 摘要 |
<p>The present invention relates to a novel series of 4-phenylpiperazines, 4-phenyl-piperidines and 4-phenyl-1,2,3,6-tetrahydropyridines compound of general formula (I) wherein A is alkylene, alkenylene, alkynylene, and C3-7 cycloalkylene; R1 is a C¿3-10? alkyl, alkenyl, or alkynyl group, cycloalk(en)yl, cycloalk(en)yl-alk(en/yn)yl, trifluoromethylsulfonyl, or alkylsulfonyl, R?2 - R5¿ are optional substituents; R?9 and R10¿ are hydrogen, alkyl or together form an ethylene or propylene bridge; W is O or S; V is O, S, CR?6R7, or NR8¿ wherein R?6, R7, and R8¿ are hydrogen or alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, optionally substituted arylalkyl or aryl, or R?6 and R7¿ constitute a 3-7 membered spiroring; Z is -(CH¿2?)m-, m being 2 or 3 or Z is -CH=CH-; X is N, C or CH; show effects on central serotonin 5-HT1A and dopamine D2 receptors. Thus the novel compounds are useful in the treatment of certain psychic and neurologic disorders in particular psychosis.</p> |
