发明名称 NEW LIPID ESTERS OF NUCLEOSIDE MONOPHOSPHATES AND THEIR USE AS IMMUNOSUPPRESSIVE DRUGS
摘要 The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I), wherein R1 represents an optionally substituted alkyl chain having 1-20 carbon atoms; R2 represents hydrogen, an optionally substituted alkyl chain having 1-20 carbon atoms; R3, R4 and R5 represent hydrogen, hydroxy, azido, amino, cyano, or halogen; X represents a valence dash, oxygen, sulfur, a sulfinyl or sulfonyl group; Y represents a valence dash, an oxygen or sulfur atom; B represents a purine and/or pyrimidine base; with the proviso that at least one of the residues R3 or R5 is hydrogen; to their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds.
申请公布号 CA2190983(A1) 申请公布日期 1995.12.07
申请号 CA19952190983 申请日期 1995.05.23
申请人 BOEHRINGER MANNHEIM GMBH 发明人 HERRMANN, DIETER;OPTIZ, HANS-GEORG;ZILCH, HARALD;MERTENS, ALFRED
分类号 A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K31/7076;A61K31/708;A61P31/12;A61P35/00;A61P37/06;C07H19/04;C07H19/10;C07H19/20;C07H19/207;(IPC1-7):C07H19/207 主分类号 A61K31/70
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