AMIDE DERIVATIVES HAVING 5HT1D-ANTAGONIST ACTIVITY

摘要

Compound of formula (I), processes for their preparation and their use as CNS agents are disclosed, in which A is CONR where R is hydrogen or C1-6alkyl; Q is an optionally substituted 5 to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur; R1 is hydrogen, halogen, C¿1-6?alkyl, C3-6cycloalkyl, COC1-6alkyl, C1-6alkoxy, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, acyl, nitro, trifluoromethyl, cyano, SR?9, SOR9, SO¿2R9, SO2NR?10R11, CO¿2R?10, CONR10R11, CO¿2NR?10R11, CONR10(CH¿2)aCO2R11, (CH2)aNR?10R11, (CH¿2)aCONR?10R11, (CH¿2)aNR?10COR11, (CH¿2)aCO2C1-6alkyl, CO2(CH2)aOR?10, NR10R11, NR10CO¿2R?11, NR10CONR10R11, CR10=NOR11, CNR10=NOR11¿, where R?10 and R11¿ are independtly hydrogen or C¿1-6?alkyl and a is 1 to 4 or R?1¿ is an optionally substituted 5 to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur; R?2 and R3¿ are independently hydrogen, halogen, C¿1-6?alkyl, C3-6cycloalkyl, C3-6cycloalkenyl, C1-6alkoxy, acyl, aryl, acyloxy, hydroxy, nitro, trifluoromethyl, cyano, CO2R?10, CONR10R11, NR10R11¿ where R?10 and R11¿ are as defined for R?1; R4 and R5¿ are independently hydrogen or C¿1-6?alkyl; R?6¿ is halogen, hydroxy, C¿1-6?alkyl or C1-6alkoxy; R?7 and R8¿ are independently hydrogen, C¿1-6?alkyl, aralkyl, or together with the nitrogen atom to which they are attached form an optionally substituted 5 to 7-membered heterocyclic ring containing one or two heteroatoms selected from oxygen, nitrogen or sulphur; m is 0 to 4; and n is 0, 1 or 2.