| 摘要 |
<p>This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R represents alkyl having 2 to 6 carbon atoms, alkenyl having 2 to 6 carbon atoms, alkynyl having 2 to 6 carbon atoms, or -(CH2)m-R3 wherein R3 represents cycloalkyl of 3 to 5 carbon atoms and m is 1 or 2; R1 represents alkyl having 1 to 4 carbon atoms; R2 represents alkyl having 1 to 5 carbon atoms, aryl or aryl substituted with halogen or alkyl having 1 to 5 carbon atoms; R4 represents alkyl having 1 to 6 carbon atoms; n is an integer from 1 to 5; p is an integer from 0 to 6; x is 0 or 2; Y represents NH, oxygen or sulfur; and Z represents hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, NR6R5 wherein R?6 and R5¿ are independently hydrogen or alkyl having 1 to 4 carbon atoms, or SR7 wherein R7 is hydrogen, benzyl or alkyl having 1 to 4 carbon atoms. The compounds of formula (I) are leukotriene B¿4? antagonists and are useful as anti-inflammatory agents and in the treatment of leukotriene B4 mediated conditions.</p> |
