TRICYCLIC DICARBONYL DERIVATIVES

摘要

Compounds of general formulae (Ia), (Ib) and (II), wherein R<1> and R<2> each independently signify hydrogen, lower alkyl, lower alkoxy, nitro, trifluoromethyl, amino, halogen, cyano or R<3>R<4>NS(O)2- and R<3> and R<4> signify lower alkyl, and R<2> can additionally signify morpholino or thiomorpholino, a 5- or 6-membered heterocycle with 1-3 N atoms optionally substituted by lower alkyl, hydroxy, amino or the group -CH2NHCH3, a bicyclic heterocycle with 1-3 N atoms or a group -NR<5>R<6> or -OR<5> in which R<5> and R<6> can be the same or different and signify hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, amino-lower alkyl or lower alkylamino-lower alkyl, and X in formula (II) signifies -CH=CH-, -CH=N-, -NH-, -CO- or -O-, as well as pharmaceutically usable salts of compounds of general formulae (Ia), (Ib) and (II). They can be used for the treatment or prevention of illnesses, especially for the treatment or prevention of ischemia, hypoglycaemia, hypoxia, cerebral vascular spasms, spasticity, trauma, hemorrhagia, infection (viral, bacterial, amoebic, prional), epileptic seizures, autoimmune diseases, withdrawal symptoms, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, intoxications, olivoponto-cerebellar atrophy, spinal cord injuries, schizophrenia, depressions, anxiety states, dependence, pains, autism and mental retardation.