| 摘要 |
Sulphonamidocarbonyl pyridine-2-carboxylic acid ester amide derivs. of formula (I) and their pyridine N-oxides are new. R1 = OH or 1-6C alkoxy; R2, R3 = H, opt. substd. 1-6C alkyl, 1-6C alkoxy, halogen (esp. F, Cl or Br), CN, OH or NH2; R6 = H, 1-6C alkyl or a N-protecting gp., a 1-4 valent cation or a cation of a basic amino acid; R7 = Y-(Y'U)rDW but not SO3H; Y = SO2 or CO; Y' = bond or 1-16C alkanediyl, 3-10C cyclic alkanediyl, 2-16C alkenediyl, 2-16C cycloalkenediyl, 2-16C alkynediyl, 2-16C alkenynediyl, opt. contg. more than 1 C-C multiple bond; U = bond, H (sic), CO, OCO, COO, CONR, NRCO, O, SO, SO2, NR; R = 1-3C alkyl or H; r = 1-4; D = bond, H (sic), 1-10C alkanediyl, 1-10C alkenediyl, 2-10C alkynediyl, 2-10C alkenynediyl, opt. contg. more than one C-C multiple bond; W = bond (sic), H, 3-10C cycloaliphatic alkyl, 3-10C alkenyl, 3-10C alkynyl or 3-10C alkenynyl, 6-16C aryl or 5-6 membered heteroaryl; R4 = H, 1-6C alkyl, Ph or phenyl(1-4C)alkyl; R5 = aliphatic 1-8C alkyl, (mono-substd. by 1-12C alkoxycarbonyl, 1-12C alkoxy(1-2C)alkoxycarbonyl, 3-8C cycloalkoxycarbonyl, 3-12C alkenyloxycarbonhyl, or 3-12C alkynyloxycarbonyl), and which is opt. substd. with one or more substitutents (sic); with provisos. |
