| 摘要 |
An aerosol formulation is disclosed which is comprised of (and may consist essentially only of) an aerosol propellant and a base form of a narcotic drug selected from the group consisting of fentanyl, sufentanil, and remifentanyl. Such a formulation allows for the drug to be dissolved within the propellant and used within a device which dose not require the use of a lubricant. Formulations are also disclosed which include lubricants, wherein the lubricant and propellant are both either polar or both non-polar. Thus, the lubricant component does not act as a solvent or cosolvent, but rather acts as a lubricant for the valve used for dispersing the formulation to a patient. Typical nonpolar propellants include chlorofluorocarbons which are typically used in connection with non-polar lubricants such as saturated vegetable oils, e.g. fractioned coconut oils. Typical polar propellants include hydrofluoroalkanes which are typically used in connection with polar lubricants such as polyethylene glycols.
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