| 摘要 |
PURPOSE: To obtain a synthetic polymeric drug that can sustain the efficacy of medicine for hours, as its side-effects are inhibited, by retarding the introduction of the active components into cells. CONSTITUTION: This synthetic polymeric drug comprises a bioactive molecule, a targeting moiety and an inert synthetic polymer carrier including the recurring units derived from N-(2-hydroxypropyl)-methacrylamide in which (A) 5.0-99.7 mol.% of the units of formula I, (B) the units bonding 0.2-20.0 mol.% of the bioactive molecule via a peptide space [NH-R-CO] that is hydrolyzable by the intracellular liposome to the polymeric carrer, (C) the units bonding 0.1-94.8 mol.% of a targeting moiety [D] directly or via the target group spacer to the polymer carrier, (D) the units bearing crosslinking chain between 0-5 mol.% of other polymeric carrier of formula IV and (E) the units bonding 0-2 mol.% of N-methacryloyl tyrosine amide to the polymeric carrier as a biologically determining label.
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