P54 STRESS-ACTIVATED PROTEIN KINASES

摘要

The p54 Stress-Activated Protein Kinases (SAPKs) are members of a large gene family and are structurally related to the previously described mitogen-activated protein kinases (MAPKs). They are distinguished by their strong activation in response to heat shock, TNF-.alpha., IL-1-.beta., sphingomyelinases, chemical protein synthesis inhibitors, and ischemia. These kinases have potential utility in the modulation of the inflammatory response and the up-regulation of repair or protective cellular proteins following injury or chemical insult.