| 摘要 |
<p>A binding partner to advanced glycosylation endproducts (AGEs) has been identified and further characterized in accordance herewith. The particular receptor in this instance is the lectin MAC-2, which has been found to bind to AGEs with a higher affinity than to carbohydrates such as its 'natural' ligand, galactose. The level of soluble MAC-2 appears to vary in a manner which commends the use of MAC-2 as a prognostic indicator of susceptibility to complications stemming from the presence and accumulation of advanced glycosylation endproducts. Both diagnostic and therapeutic uses of this AGE receptor are disclosed, as are pharmaceutical compositions containing the receptor or active portions thereof, for use in treating disorders attributable to the presence and/or accumulation of advanced glycosylation endproducts.</p> |
