Indoline derivatives method of preparation and use

摘要

PCT No. PCT/EP94/04220 Sec. 371 Date Jun. 14, 1996 Sec. 102(e) Date Jun. 14, 1996 PCT Filed Dec. 20, 1994 PCT Pub. No. WO95/17405 PCT Pub. Date Jun. 29, 1995A compound of formula (I) (I) wherein, R1 is hydrogen, halogen or C1-6 alkyl; R2 is a group of formula -CR3R4(CH2)pNR5COR6; R3, R4 and R5, which may be the same or different, are hydrogen or Cl-6 alkyl; R6 is C1-6 alkyl or C3-7 cycloalkyl; n is an integer of 2, 3 or 4; p is an integer of 1, 2, 3 or 4; and pharmaceutically acceptable salts and solvates thereof. A compound of formula (I) is useful in the treatment of conditions associated with a disturbed functioning of the melatonin system.