发明名称 |
DNA molecules having human bcl-2 gene sequences |
摘要 |
The sequence of the protein coding regions of the _b-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. This translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.
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申请公布号 |
US5459251(A) |
申请公布日期 |
1995.10.17 |
申请号 |
US19940228704 |
申请日期 |
1994.04.18 |
申请人 |
THE WISTAR INSTITUTE |
发明人 |
TSUJIMOTO, YOSHIHIDE;CROCE, CARLO A. |
分类号 |
C12N15/09;C07K14/00;C07K14/005;C07K14/195;C07K14/435;C07K14/82;C07K16/00;C12N15/12;C12P21/00;C12P21/02;C12P21/08;C12Q1/68;C12R1/01;G01N33/574;G01N33/577;(IPC1-7):C12N15/12 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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