| 摘要 |
The present invention provides methods for producing linear thiopeptides using an amino acid ortho amino thioanilide compound of formula (III) <IMAGE> (III) wherein R1 is selected from the group consisting of hydrogen or C1-C4 branched or unbranched alkyl; R2 is selected from the group consisting of hydrogen, halo, amino, hydroxy, C1-C4 branched or unbranched alkoxy, guanido, amido, acyl, carboxy, cyano, mercapto, nitro, azido, and C1-C4 branched or unbranched alkyl optionally substituted by halo, amino, hydroxy, C1-C4 branched or unbranched alkoxy, guanido, amido, acyl, carboxy, cyano, mercapto, nitro, azido; R3 is a decarboxylated amino acid residue or a decarboxylated amino acid chain comprising at least two amino acid residue.
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