发明名称 |
Thrombin-inhibitory proteins from terrestrial leeches |
摘要 |
PCT No. PCT/EP92/02661 Sec. 371 Date May 18, 1994 Sec. 102(e) Date May 18, 1994 PCT Filed Nov. 19, 1992 PCT Pub. No. WO93/11239 PCT Pub. Date Oct. 6, 1993.Novel thrombin-inhibitory proteins from terrestrial leeches of the genus Haemadipsa with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Thr-Cys-Asp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser-Gly-Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys, or an amino-acid sequence which is obtained by C-terminal truncation of this sequence by from one to twelve amino acids, are described. The proteins are suitable for controlling diseases. Also described are the nucleic acids coding for these proteins.
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申请公布号 |
US5455181(A) |
申请公布日期 |
1995.10.03 |
申请号 |
US19940244113 |
申请日期 |
1994.05.18 |
申请人 |
BASF AKTIENGESELLSCHAFT |
发明人 |
STRUBE, KARL-HERMANN;BIALOJAN, SIEGFRIED;KROEGER, BURKHARD;FRIEDRICH, THOMAS |
分类号 |
A61K38/55;A61K38/00;A61P7/02;C07K14/00;C07K14/435;C07K14/81;C07K14/815;C12N15/09;C12N15/15;C12P21/02;C12R1/19;(IPC1-7):C12N15/00;C12P21/06;C07K1/00 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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