| 摘要 |
1-Biphenylylmethyl-benzimidazole derivs. of formula (I) and their tautomers and salts are new: R1 = F, Cl, Br, 1-3C alkyl or CF3; R2 = opt. substd. C-bonded 5-membered heteroaryl contg. one heteroatom (NH, O or S) or two heteroatoms (NH and O, S or N), opt. fused to another ring; a pyrrolidino, piperidino or hexamethylenimino gp. in which a CH2 gp. is replaced by CO or SO2; opt. substd. maleimido (opt. substd. by 1-3C alkyl or phenyl), or opt. substd. 2,4-dioxo-3-imidazolidinyl; R3 = 1-4C alkyl, 3-5C cycloalkyl, 1-3C alkoxy or 1-3C alkylthio; R4 = opt. substd. amino, substd. sulphonyl, C(NH)NHOH; 2,4-dioxo-5-thiazolidinylidenemethyl; or 5-oxo-1,2,4-oxadiazol-3-yl.
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| 申请人 |
DR. KARL THOMAE GMBH, 88400 BIBERACH, DE |
发明人 |
MIHM, GERHARD, DIPL.-CHEM. DR., 88440 BIBERACH, DE;HAUEL, NORBERT, DIPL.-CHEM. DR., 88433 SCHEMMERHOFEN, DE;RIES, UWE, DIPL.-CHEM. DR., 88400 BIBERACH, DE;MEEL, JACPUES VAN, DR., 88441 MITTELBIBERACH, DE;WIENEN, WOLFGANG, DIPL.-BIOL. DR., 88437 AEPFINGEN, DE;ENTZEROTH, MICHAEL, DIPL.-CHEM. DR., 88447 WARTHAUSEN, DE |
