A87689 compounds

摘要

Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C1-6-alkyl ether and C1-6-alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A2 inhibitors that are also useful as antiinflammatory agents.