Anti-IGM monoclonal antibodies and methods for their use

摘要

This invention relates to anti-IGM antibody conjugates which comprise: a monoclonal antibody which binds selectively to IgM antibody, which does not bind to IgG1 or IgG2 antibody and which belongs to isotype G, and a cytotoxic group conjugated with the said monoclonal antibody. This invention also relates to a method for selecting hybridomas producing monoclonal antibodies belonging to the IgG isotype which comprises treating a population of hybrid cells with a monoclonal antibody belonging to isotype G which selectively binds to the IgM antibody but which does not bind to IgG1 or IgG2 antibody, selecting the said resulting cells which form an immune complex and collecting the cells which do not form a complex with the said antibodies.