发明名称 |
Ruiskeena annettavat liposomilääkevalmisteet |
摘要 |
Stable, parenteral formulations in the form of liposomes of 35-200nm diameter contain (a) a lipophilic active agent (I), which is difficult to dissolve, and a phospholipid (II) as liposome membrane component, with wt. ratio (I):(II) = 1-20:200; and (b) a fatty acid stabiliser of formula H3C-(CH2)n-COOA (III) in an amt. of 0.3-10 mg/ml of finished soln. A = H or mono- or di-valent cation; n = 4-8. Pref. (I) is nimodipine or another dihydropyridine; and the formulation contains a disaccharide as cryoprotector, esp. 0.4-0.8 pts. wt. sucrose per pt. wt. phospholipid.
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申请公布号 |
FI954204(A0) |
申请公布日期 |
1995.09.08 |
申请号 |
FI19950004204 |
申请日期 |
1995.09.08 |
申请人 |
BAYER AKTIENGESELLSCHAFT |
发明人 |
HAMANN, HANS-JUERGEN;SERNO, PETER;HERBOTH, MATTHIAS;KURKA, PETER |
分类号 |
A61K31/20;A61K9/00;A61K9/127;A61K31/4422;A61K31/47;A61K31/4709;A61K31/685;A61K47/12;A61K47/26;A61P39/00;A61P43/00;(IPC1-7):A61K |
主分类号 |
A61K31/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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