| 摘要 |
PURPOSE:To obtain a new compound, having inhibiting activities against sphingomyelinases and useful as an anti-HIV agent, an antidiabetic agent, an antiarteriosclerotic agent, an antithrombotic agent, an antiinflammatory agent, an immunosuppressant, a diuretic agent, a preventing and therapeutic agent, etc., for Alzheimer diseases. CONSTITUTION:This compound F-10463a is expressed by the formula. properties: colorless oily substance; solubility: soluble in organic solvents such as methanol or ethyl acetate and insoluble in water; color test: positive to 50% sulfuric acid and iodine; molecular formula: C29H43NO5: molecular weight (measured value):485; molecular weight (calculated value) : 486.3204. The compound is obtained by culturing microorganism, which belong to the genus Dasyscyphus and capable of producing the compound F-10463a [e.g. Dasyscyphus mollissimus (Lasch) Dennis-SANK13892 strain (FERM BP-4491)] and collecting the compound from the resultant culture. The culturing is preferably carried out At 15-30 deg.C under aerobic conditions according to a submerged culture method. |
