| 摘要 |
A method of treatment (including therapy and prophylaxis) of animals of one or more clinical conditions selected from: seizures, neurological disorders such as epilepsy and conditions in which there is neurological damage such as brain trauma, cerebral ischaemia, haemorrhage, head injuries and stroke; which comprises administering to an animal in need thereof a therapeutically and/or prophylactically effective amount of one or more compounds of formula (I), including all pharmaceutically acceptable salts thereof in which: R<1> represents C1-6 alkyl, pyridyl or (when Y is other than a bond) H; R<2> and R<3> independently represent H, C1-4 alkyl or formyl; R<4> and R<5> independently represent H, halo, phenyl, trifluoromethyl, C1-3 alkyl or C1-3 alkoxy; or if R<4> and R<5> are on adjacent carbon atoms, R<4> and R<5> together with the carbon atoms to which they are attached represent a second benzene ring, which is optionally fused to a third benzene ring; and Y represents a bond or methylene (optionally substituted with one or two C1-3 alkyl). A particularly preferred compound of formula (I) for administration in the above method of treatment is <u>N</u>,<u>N</u>-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine (sibutramine) especially in the form of its hydrochloride and/or hydrochloride monohydrate salts. |
