METHOD FOR THE PREPARATION OF ENANTIOMERICALLY PURE POLYHYDROXYLATED NITROGENOUS HETEROCYCLES

摘要

Process for the preparation of enantiomerically pure polyhydroxylated nitrogenous heterocycles having formula (I) and of their enantiomers, wherein G1, R1, R2, R3 and n are as defined in the description, consisting in (a) reacting an amine having the formula (II): R1-NH2 with a bis-epoxyde, enantiomerically pure and having a symmetry axis C2, having formula (III) to obtain a mixture of the piperidinic derivative and the azepanic derivative; (b) separating the piperidinic derivative from the azepanic derivative; (c) optionally replacing the protection groups of the functions alcohol and/or the rest -alk(1C)-Ar representing the substituent R1 of the compounds obtained at (b) by hydrogen atoms.