Amphotericin B composition with enhanced fungal activity

摘要

Fungal infections are treated by administering a combination of (a) amphotericin B, and (b) a glycerol ether selected from the group consisting of (i) HOCH2CHOHCH2OR, (ii) HOCH2CH(OR1)CH2OH, and (iii) combinations thereof, wherein R and R1 are independently selected from the group consisting of C8-C18 and C8-C18 alkenyl. The glycerol ether acts synergistically to reduce the minimum inhibitory concentration of amphotericin B. The combination is particularly effective against Cryptococcus and Candida species.