| 摘要 |
<p>This invention concerns compounds of generic formula (I) or a pharmaceutically acceptable salt thereof, where the dotted line represents an optional bond, one of R?1 and R5¿ represents hydrogen, C¿1?-C6 alkyl, C7-C16 aralkyl, -(CHR?6)¿nCHR7CN, -(CHR6)nCHR7CONH2, -(CHR6)nCHR?7COOR8, -(CHR6)¿nCHR7CH2OH wherein n is 0 or 1, R?6 and R7¿ independently represent hydrogen, C¿1?-C6 alkyl- or C7-C16 aralkyl-, and R?7¿ also represents hydroxy(C¿1?-C6)alkyl-, (C2-C7)alkanoyloxy(C1-C6)alkyl-, (C1-C6alkoxy)carbonyl- and R?8¿ is hydrogen or C¿1?-C6 alkyl; the other of R?1 and R5¿ is hydrogen, C¿1?-C6 alkyl or C7-C16 aralkyl; R?3 is C¿6-C10 aryl or heteroaryl group optionally substituted by one or more substituents the same or different, R?2 and R4¿ independently represent hydrogen, or a group of formula -CRaRbRc where R?a, Rb and Rc¿ are independently selected from hydrogen, C¿1?-C6 alkyl, optionally substituted C6-C10 aryl, optionally substituted heteroaryl, C1-C6 alkyl substituted by optionally substituted C6-C10 aryl or heteroaryl or R?2¿ also represents COR11 where R11 is C1-C6 alkyl, C1-C6 alkoxy or an optionally substituted (C6-C10 aryl)alkyl or a heteroaryl alkyl radical; one of Y and Y1 is (a), (b) or (c), where R13 represents hydrogen, C¿1?-C6 alkyl or C7-C16 aralkyl; the other of Y and Y1 is -CHR?12¿- where R12 is hydrogen, C¿1?-C6 alkyl or C7-C16 aralkyl, which compounds have pharmaceutical uses conferred by their ability to block voltage gated potassium channels.</p> |
