| 摘要 |
<p>A 1 alpha ,24-(OH)2-vitamin D3 cream comprising: (a) a therapeutically available quantity of 1 alpha ,24-(OH)2-vitamin D3; (b) an oily phase component comprising: (i) a solid oil component comprising 5-20 parts by weight of white vaseline and 5-15 parts by weight of a higher alcohol, and (ii) a liquid oil component comprising 3-10 parts by weight of squalane; (c) an aquous phase component; and (d) 2.5-7.5 parts by weight of two or more surfactants, wherein the ratio of the solid oil component to the liquid oil component is about 2 or above, the higher alcohol is a mixture of stearyl alcohol with cetyl alcohol with the weight ratio of stearyl alcohol to the mixture being about 0.65 to about 0.9, at least 50 % by weight of the surfactants is at least one surfactant having an HLB value of about 5 or less, and the HLB value of the surfactants as a whole is about 8 to about 18. <IMAGE></p> |
