| 摘要 |
This invention is directed to compounds of formula (I), wherein R<1> is an optionally substituted lower alkyl group; R<2> is an optionally substituted oxaaliphatic group; R<3> is an optionally substituted aryl group or an optionally substituted heteroaryl group; Q<1>, Q<2> and Q<3> are independently nitrogen, CX or CH; Z<1> is oxygen or sulfur; Z<2> is -CH=CH-, -CC-, -CH2-CZ-, -CZCH2-, -CZ-CZ-, -CH2-NH-, -CH2-O-, -CH2-S-, -CX2-O-, -CZNH-, -NH-CH2-, -O-CH2_, -SCH2-, -SOCH2-, -SO2CH2-, -O-CX2-, -O-CZ-, -NH-CZ-, -N=N-, -NH-SO2-, -SO2-NH-, -CZ-CZ-NH-, -NH-CO-O-, -O-CO-NH- or -NH-CO-NH-; Z is oxygen or sulfur; and X is halo; or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which possess useful pharmaceutical properties. They are especially useful for inhibiting the production or physiological effects of TNF and inhibit cyclic AMP. The present invention is also directed to their pharmaceutical use, pharmaceutical compositions containing the compounds, and methods for their preparation. |
