| 摘要 |
PCT No. PCT/FI91/00396 Sec. 371 Date Oct. 20, 1993 Sec. 102(e) Date Oct. 20, 1993 PCT Filed Dec. 18, 1991 PCT Pub. No. WO92/11268 PCT Pub. Date Jul. 9, 1992.The invention relates to novel methylenebisphosphonic acid ester amide derivatives of general formula (I), in which formula W1, W2, W3 and W4 are independently the group OR1 or the group NR2R3 wherein R1, R2 and R3 independently are hydrogen or straight or branched, optionally unsaturated C1-C22-alkyl, optionally substituted, optionally unsaturated C3-C10-cycloalkyl, aryl, aralkyl or silyl SiR3, or the groups R2 and R3 form together with the adjacent nitrogen atom a 3 to 10-membered saturated, partly saturated or aromatic heterocyclic ring, wherein in addition to the nitrogen atom, there may be one or two heteroatoms from the group N, O and S, provided that in formula (I) at least one of the groups W1, W2, W3 and W4 is hydroxy and at least one of the groups W1, W2, W3 and W4 is amino group NR2R3, Q1 and Q2 are independently hydrogen, fluorine, chlorine, bromine or iodine, including the stereoisomers, such as the geometrical isomers and the optically active isomers, of the compounds, as well as the pharmacologically acceptable salts of the compounds.
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