A variant and so-called "escape mutant" HBsAg protein or fragment thereof displaying the antigenicity of hepatitis B virus surface antigen is disclosed, in which the mutant protein or fragment thereof (mHBsAg) comprises a modified 'a' determinant in which at least two amino acids are inserted downstream of position (122) of the wild type HBsAg sequence. A vaccine comprising the mHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-mHBsAg antibodies and an antibody preparation comprising anti-mHBsAg antibodies.
申请公布号
WO9521189(A1)
申请公布日期
1995.08.10
申请号
WO1995GB00208
申请日期
1995.02.02
申请人
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE;KARAYIANNIS, PETER;THOMAS, HOWARD, CHRISTOPHER