Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein.

摘要

Novel peptide and peptide mimetic ligands which act as inhibitors of p34<cdc2> kinase, p33<cdk2> kinase and human papillomavirus transforming protein E7 (HPV E7) are disclosed. The inhibitors are derived from the binding domains of a retinoblastoma tumor suppressor protein (Rb), p107 and a cyclin.