RECOMBINANT INFECTIOUS BOVINE RHINOTRACHEITIS VIRUS MUTANT, METHODS FOR THE PRODUCTION OF SAME, AND VACCINES CONTAINING THE SAME

摘要

Infectious Bovine Rhinotracheitis Virus mutant, methods for the production of same, and vaccines containing the same. The obtained virus, characterized as BHV-1 FM gll-, results from one deletion, from one insertion, or from one substitution (deletion and insertion) in the gene gll (gE) from Bovine Herpesvirus type 1 (BHV-1), which fails to produce any antigenic polypeptide of glycoprotein gll (gE). BHV-1 FM gllvirus is utilized in the preparation of vaccines for Infectious Bovine Rhinotracheitis. These vaccines allow to distinguish serologically between animals vaccinated with the same and animals infected with field strains of IBR virus.