| 摘要 |
PCT No. PCT/DE91/00562 Sec. 371 Date Jun. 1, 1993 Sec. 102(e) Date Jun. 1, 1993 PCT Filed Jul. 5, 1991 PCT Pub. No. WO92/00991 PCT Pub. Date Jan. 23, 1992.The unsaturated 17 alpha -cyanomethyl-17 beta -hydroxy steroids of the formula I, <IMAGE> in which R1=Me, Eth; R2=H, Me; R3=H, OH, an acetoxy or alkoxy group; R4=H, R5=OH, an acetoxy, alkoxy group of R4 and R5 together represent a keto- or ketal group and double bonds are contained in the basic structure of the steroid, particularly between the 15 and 16 position in the steroid ring, from unsaturated 17-ketosteroids of the general formula II as described herein with the aforementioned meanings of R1 to R5 by reacting the unsaturated 17-ketosteroids with LiCH2CN and subsequently hydrolyzing. The compounds of formula I are pharmacologically interesting steroid compounds or also intermediate products for the synthesis of highly-effective steroid products which can be used in human and veterinary medicine for the treatment of endocrine disorders and for reproductive control based on their specific hormonal/anti-hormonal actions. The compounds are suitable for the treatment of endometriosis and also in combination with preparations with ethinylestradiol for fertility control.
|
