| 摘要 |
PURPOSE: To obtain an orally administrable pharmaceutical composition considerably increased in biocompatibility by dispersing a staurosporine active ingredient in a saturated polyalkylene glycol glyceride. CONSTITUTION: This orally administrable pharmaceutical composition is obtained by dissolving or dispersing a staurosporine as an active ingredient in a saturated polyalkylene glycol glyceride and providing a solution or a dispersion of the active ingredient. N-Benzoylstaurosporine is preferred as the staurosporine active ingredient. The amount of the active ingredient is preferably 1-30 wt.%, especially preferably 10-20 wt.% in the composition. The glycol glyceride is preferably a mixture of a glyceryl ester of an 8-18C saturated fatty acid with a polyethylene glycol ester. The polyethylene glctol ester preferably has 1,400-1,600 molecular weight. The pharmaceutical composition is preferably formulated by especially melting the saturated polyalkylene glycol glyceride, mixing the active ingredient with the molten glyceride and solidifying the resultant mixture. |
