Oral dosage form of desmopressin (ddavp)

摘要

dDAVP oral delivery systems are described wherein dDAVP retains good biological activity. In the preferred embodiment, dDAVP protein microspheres are made by emulsifying a solution of a protein such as zein and dDAVP with an immiscible solvent. Pellets containing the microspheres are prepared by an extrusion and spheronisation process, and are placed in a hard gelatin capsule. Release of biologically active dDAVP is achieved when the capsules are administered in vivo to cynomolgus monkeys.