发明名称 |
Process for the synthesis [R-(R*-,R*-)]-5-(3-chlorophenyl-3-[2-(3,4-dihydroxyphenyl)-1-methylethyl]-2-oxazolidinone |
摘要 |
The invention is the simultaneous addition of boron tribromide and a solution of [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2-oxazolidinone in methylene chloride to methylene chloride while maintaining a constant ratio of 2.10:1.00 of boron tribromide to the substrate [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2-oxazolidinone at a temperature of -5 DEG C. to 10 DEG C. gives [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-hydroxyoxyphenyl)-1-methylethyl]-2-oxazolidinone in an isolated yield of 86.7% and a purity of 98.7%.
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申请公布号 |
US5438148(A) |
申请公布日期 |
1995.08.01 |
申请号 |
US19940309303 |
申请日期 |
1994.09.20 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
MOHAN, ARTHUR G.;BLUM, DAVID M. |
分类号 |
C07D263/20;(IPC1-7):C07D263/20 |
主分类号 |
C07D263/20 |
代理机构 |
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主权项 |
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地址 |
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