| 摘要 |
FIELD: organic chemistry. SUBSTANCE: product: compounds of the general formulawhere: X - carbonyl or sulfonyl; Y - bond or lower alkylene; R- halogen, lower alkyl, haloid(lower)alkyl, aryloxy, nitro or amino that can has 1 or 2 similar or different substituents taken from lower alkyl, acyl and lower alkanosulfonyl; R- aryl or aromatic hetero(mono- or bi-)cyclic group each of that can has 1, 2 or 3 suitable substituents; R- hydrogen or lower alkyl; R- (!) group of the formula -SO-R, where Ris lower alkyl or aryl optional substituted with lower alkyl or lower alkoxy, (!!) group of the formulawhere R- aryl optional substituted with lower alkyl or lower alkoxy, or (!!!) group of the formula -A-(Z), where A - bond, lower alkylene, lower alkenylene or lower alkynylene; Z - hydrogen, halogen, hydroxy, nitrile, amino, cyclo(lower)alkyl, aryl, aryloxy, acyl, acylamino, lower alkanesulfonylamino, arylsulfonylamino or aromatic hetero(mono- or bi-)cyclic group and each of cyclic groups can has 1, 2 or 3 suitable substituents, and p = 1, 2 or 3, and n = 0, 1 or 2. Condition: when n or p is above 1 then Rand Z can be similar or different groups, respectively. Invention describes pharmaceutically acceptable salts and methods of synthesis of indicated compounds and composition based on thereof. Synthesized compounds show pharmacological activity exhibiting antagonism to tachykinin, neurokinin and can be used in medicine. EFFECT: improved method of synthesis. |
