PRODUCTION OF 4,6-DIALKOXY-2-HYDROXYMETHYLPYRIMIDINE DERIVATIVE

摘要

PURPOSE:To efficiently produce a 4,6-dialkoxy-2-hydroxymethylpyrimidine useful as a synthetic intermediate for phenoxymethylpyrimidine derivatives by reacting a specific pyrimidine derivative with an alcohol in the presence of a metallic alkoxide. CONSTITUTION:This method for producing a 4,6-dialkoxy-2- hydroxymethylpyrimidine derivative expressed by formula II (R is a lower alkyl) is to react a pyrimidine derivative expressed by formula I {R' is an alkyl different from R; A is H or C(=0)-Q [Q is a lower alkyl or a (substituted) phenyl]} with an alcohol expressed by the formula ROH in the presence of a metallic alkoxide.