Process for the preparation of glycerophospholipids

摘要

A process for fractionating deacylated glycerophospholipids of the formula (I): <IMAGE> (I) wherein R is a negative charge; a hydrogen atom; a CH2CH2NR1R2 residue wherein R1 and R2, which are the same or different, are H or C1-C4 alkyl; a CH2CH2N+ (CH3)3 residue; a CH2CH(NH2)COOH residue or a residue of the formula: <IMAGE> and X is OH or 0-, is described. The process involves subjecting an aqueous or hydroalcoholic mixture of two or more of the deacylated glycerophospholipids to electrodialysis in an electrolytic cell comprising a number of compartments. The compartments are separated by cation-exchange membranes, anion-exchange membranes or both cation-exchange and anion-exchange membranes, at a pH effective to differentiate the deacylated glycerophospholipids.