| 摘要 |
<p>PURPOSE:To obtain the subject elcatonin preparation useful as an injection, having stability to shaking, heat and light by packing an aqueous solution composition comprising elcatonin as an active ingredient to a container made of glass subjected to alkali removal treatment. CONSTITUTION:This preparation is obtained by packing an aqueous solution composition (preferably a composition for injection having pH of 5.0-6.5 and of ionic strength (mu) 0.01-0.5) comprising elcatonin [chemical name: 1-butyric acid-7-(L-2-aminobutyric acid)-26-L-aspartic acid-27-L-valine-29-L-alaninecalcitonin (salmon)] as an active ingredient into a container made of glass (preferably ampule or a container made of vial glass) subjected to alkali removal treatment, for example, by bringing an aqueous solution of ammonium sulfate into contact with an inner wall of the container, heating and then cleaning the container by ultrasonic wave.</p> |
