Metabotropic receptor mGluR7 is identified and sequenced. The mGluR7 receptor subfamily mediates inhibition of transmitter release at selected glutamatergic synapses. The receptors, mGluR7-specific peptides and antibodies thereto are used to identify agonists and antagonists of G protein coupled glutamate receptor mediated neuronal transmitter release, as well as in methods of diagnosis and therapy.
申请公布号
WO9518154(A1)
申请公布日期
1995.07.06
申请号
WO1994US14989
申请日期
1994.12.29
申请人
ZYMOGENETICS, INC.;STATE OF OREGON, ACTING BY AND THROUGH THE OREGON