发明名称 |
Method for detecting antibodies to a neuroblastoma antigen in mental illness |
摘要 |
The subject invention provides an antigen characterized as having a molecular weight of approximately 68 kD, being reactive with autoantibodies associated with mental illness especially schizophrenia, being located in neuronal cells, and co-migrating with a protein band in SDS-PAGE which is recognized by rabbit antibodies which react with the peptide whose sequence is Ala-Lys-Xaa-Val-Lys-Phe-Gly-Ala-Asp-Ala-Xaa-Ala-Leu-Met-Leu (SEQ ID NO: 2). The invention also provides methods for detecting in a sample from a subject the presence of an antibody to the neuronal antigen, determining the propensity of a subject toward a psychiatric disease, diagnosing and treating a subject having mental illness.
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申请公布号 |
US5429929(A) |
申请公布日期 |
1995.07.04 |
申请号 |
US19910688748 |
申请日期 |
1991.04.19 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
LATOV, NORMAN;SADIQ, SAUD A.;GORMAN, JACK M.;KILIDIREAS, COSTAS |
分类号 |
G01N33/68;(IPC1-7):G01N33/543;G01N33/564 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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