PHARMACEUTICAL COMPOSITIONS CONTAINING CEFTRIAXONE AND PENEMS

摘要

Pharmaceutical formulations comprising ceftriaxone in combination with a penem of formula (I) in which R<1> is hydrogen or an organic group; R<2> is a ring system of formula (II), wherein R<4> and R<5> are hydrogen or one or more substituents; m is 2 or 3; p is 0, 1 or 2; R<3> is hydrogen, a pharmaceutically acceptable salt-forming cation or a pharmaceutically acceptable in-vivo hydrolysable ester-forming group; and with a pharmaceutically acceptable carrier. The formulations have antibacterial activity, the compound of formula (I) acting as a beta -lactamase inhibitor.