发明名称 Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex.
摘要 <p>A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma-membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies binding to X- or Y-SAM proteins, essentially free of antibodies binding to Y- or X-SAM proteins respectively, or to the H-Y antigen. Semen samples enriched for X- or Y-sperm. Methods for increasing the probability that offspring will be male or female comprising the step of allowing a sperm from an enriched semen sample to fertilize an ovum. Methods for increasing the probability that offspring will be male or female comprising the step of immunizing a female with X- or Y-SAM proteins. Methods of decreasing fertility comprising the step of immunizing a female with both X- or Y-sperm. Methods of increasing the probability that mammalian offspring will carry a gene for a particular sex-chromosome linked trait.</p>
申请公布号 EP0658345(A1) 申请公布日期 1995.06.21
申请号 EP19950102737 申请日期 1989.05.12
申请人 CYTOGAM, INC. 发明人 SPAUDLING , GLENN F.
分类号 A61K35/52;A61K38/00;C07K14/705;C07K16/28;C12P21/08;G01N33/50;G01N33/52;G01N33/569;G01N33/68;(IPC1-7):A61K35/52 主分类号 A61K35/52
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