| 摘要 |
The problems in crystallization of alpha -L-aspartyl-L-phenylalanine methyl ester, namely, problems in crystal slurry properties in solid-liquid separation, scaling at heat transfer surfaces, and the like, are solved by a method for crystallization of alpha -L-aspartyl-L-phenylalanine methyl ester which comprises cooling a solution of alpha -L-aspartyl-L-phenylalanine methyl ester by indirect heat exchange with a coolant while stirring, wherein the solution is cooled by circulating a coolant while continuously adding an aqueous solution of alpha -L-aspartyl-L-phenylalanine methyl ester dropwise to a crystallizing solution of alpha -L-aspartyl-L-phenylalanine methyl ester having a temperature difference of not greater than 20 DEG C. from the coolant, thereby to keep a temperature difference of not greater than 20 DEG C. between the coolant and the crystallizing solution.
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