2-substituted adenosines with A-2 receptor affinity
摘要
The compound (R)-2-[(phenylisopropyl)amino]adenosine whose structure is given below: <IMAGE> (R)-2-[(phenylisopropyl)amino]adenosine is about two orders of magnitude greater in its selectivity between the A-1 and A-2 adenosine receptors than its diastereoisomer. This compound is useful for lowering blood pressure.
申请公布号
US5426101(A)
申请公布日期
1995.06.20
申请号
US19940306847
申请日期
1994.09.15
申请人
MERRELL DOW PHARMACEUTICALS INC.
发明人
PEET, NORTON P.;BORCHERDING, DAVID R.;LENTZ, NELSEN L.;WEINTRAUB, PHILIP M.;KASTNER, PHILIP R.
