Derivatives of 1,4-Diaza-Bicyclo-(4,4,0) Benzo (1,2,h)-Decane and process for their preparation

摘要

1,158,393. Derivatives of 1,4-diazabicyclo(4, 4,0)benzo(1,2-h)decane. SCIENCE UNION ET CIE, SOC. FRANCAISE DE RECHERCHE MEDICALE. 19 May, 1967 [25 May, 1966], No. 23367/66. Heading C2C. The invention comprises compounds of formula wherein R is Y-Ar or Z-CR1R2R3, Y is a C 1 _ 4 alkylene chain, Ar is Ph (except when n = 1) or Ph substituted by halogen, CF 3 , OH, C 1 _ 5 alkyl or alkoxy or by -O-(CH 2 ) 1-2 -O-, Z is a direct link or a C 1 _ 4 alkylene chain, R1 is H, Ph or OH, R2 is Ph or cyclohexyl, and R3 is Ph possibly substituted by halogen, CF 3 or C 1-5 alkyl or alkoxy ; and their acid addition salts. Therapeutic compositions for oral, rectal or parenteral administration comprise the above compounds, which have a parasympathicolytic, anticholinergic, antispasmodic or antiserotorin activity.