| 摘要 |
<p>PURPOSE:To obtain a new glyceroglycolipid having strong carcinogenic promoter inhibiting action and low cytotoxicity and useful as a carcinogenic promoter inhibitor effective as an active component of a cancer preventing or treating agent, etc. CONSTITUTION:New glyceroglycolipid is expressed by formula I (R is H or a hydroxyl-protecting group; R<1> and R<2> are an acyl residue of a 12-24C fatty acid provided that at least one of R<1> and R<2> is eicosapentaenoyl or docosahexaenoyl) (e.g. 1-O-eicosapentaenoyl-2-O-myristoyl-3-O-beta-D- galacropyranosyl-sn-glycerol), and has strong carcinogenic promoter inhibiting action and low cytotoxicity, and is effective as a cancer preventing or treating agent. The compound can be produced by reacting a brominated alpha-D- galactopyranosyl of formula II (Ac is acetyl) with 1, 2-di-O-benzylglycerol of formula III (Bn is benzyl) and subjecting the reaction product to the deprotection of hydroxyl group, protection and acylation.</p> |
